The team and its role within CYSTINET-Africa
The School of Veterinary Medicine at the University of Zambia is one of the institutions participating in the Cysticercosis and Taeniosis Network of Sub-Saharan Africa (CYSTINET-AFRICA. Under this collaborative project, Zambia has proposed to establish a T. solium Experimental Pig Infection Model (TEPIM). The project in Zambia is therefore called BMBF-TEPIM Project. The main task of the project is to establish a reliable and reproducible porcine cysticercosis infection model, to explain preliminary field-findings of breed susceptibility to cysticercosis and to address further aspects of basic research on the disease in more detail. Since cysticercosis infection in pigs closely resembles the infection in humans, it serves as a good model to study the disease of both pigs and humans in detail, which emphasizes the one-health aspect of the disease. Besides, pigs are widely being used in translational research as they share anatomic and physiologic characteristics with humans. The primary aim of the study is to establish and an experimental pig model so as to conduct basic research on T. solium cysticercosis. The T. solium proglottids will be collected from human taeniosis carriers. The collection of these proglottids from adult tapeworms’ carriers will be done based on a community-based, cross-sectional study of T. solium cysticercosis/taeniosis (TSCT) prevalence in highly endemic provinces of Zambia.
FUNCTIONS OF MIH WITHIN THE CONSORTIUM:
- Development of the experimental pig infection model TEPIM.
- Establish a reliable and reproducalbe cysticercosis infection model to conduct basic research on T. solium cysticercosis.