Neurocysticercosis (NCC) is considered the most common helminth infection of the human nervous system and the most frequent preventable cause of epilepsy in sub-Saharan Africa. Since helminths have evolved co-evolutionary with mankind, they have developed multiple strategies to escape recognition by their hosts’ immune system resulting in a heterogeneous immune profile. An essential prerequisite to study the underlying immunological pathomechanisms that influence the development of symptomatic NCC is well-structured recruitment of patients with T. solium (neuro)cysticercosis/taeniosis (TSCT/NCC). In this proposal, a comprehensive field data collection in a highly endemic area of northern Mozambique for the calculation of prevalence proportions of TSCT/NCC (adults and children) will be complemented with clinical and immunological work-up.
The Department of Parasitology of Medical Faculty, of the Eduardo Mondlane University and the Mozambique Institute for Health Education and Research (MIHER), from Mozambique, members of this consortium, are the institutions which will take care of the research of the epidemiology of T. solium cysticercosis/taeniosis with special emphasis on neurocysticercosis and its related immunological pathomechanisms in northern Mozambique.
FUNCTION WITHIN CONSORTIUM
1. Provide data on human health, particularly prevalence of TSCT/NCC, pathomechanisms of NCC and treatment related data in immunocompetent subjects.